Papers


November 9, 2020

Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells

Brent M. Kuenzi, Jisoo Park, Samson H. Fong, Kyle S. Sanchez, John Lee, Jason F. Kreisberg, Jianzhu Ma, & Trey Ideker

1 October, 2021

Interpretation of cancer mutations using a multiscale map of protein systems

Fan Zheng, Marcus R. Kelly, Dana J. Ramms, Marissa L. Heintschel, Kai Tao, Beril Tutuncuoglu, John J. Lee, Keiichiro Ono, Helene Foussard, [...], & Trey Ideker

September 22, 2021

Biologically informed deep neural network for prostate cancer discovery

Haitham A. Elmarakeby, Justin Hwang, Rand Arafeh, Jett Crowdis, Sydney Gang, David Liu, [...], William C. Hahn & Eliezer M. Van Allen

June 21, 2023

A multi-scale map of protein assemblies in the DNA damage response

Anton Kratz, Minkyu Kim, Marcus R. Kelly, Fan Zheng, Christopher A. Koczor, Jianfeng Li, Keiichiro Ono, Yue Qin, Christopher Churas, [...], & Trey Ideker

May 4, 2021

Multi-resolution modeling of a discrete stochastic process identifies causes of cancer

Adam Yaari, Maxwell Sherman, Oliver C Priebe, Po-Ru Loh, Boris Katz, Andrei Barbu, & Bonnie Berger

March 22, 2024

Learning to target CDK4/6 inhibitor resistance via a breast cancer-specific atlas of cellular mechanisms

Adam Yaari, Eduardo Farias, Francisco Guedes, Oliver Priebe, Lee McDaniel, Tyler Earnest, Trey Ideker, & Maxwell Sherman

March 5, 2024

A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

Sungjoon Park, Erica Silva, Akshat Singhal, Marcus R. Kelly, Kate Licon, Isabella Panagiotou, Catalina Fogg, Samson Fong, [...], & Trey Ideker

March 1, 2024

Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress

Xiaoyu Zhao, Akshat Singhal, Sungjoon Park, JungHo Kong, Robin Bachelder, & Trey Ideker

December 1, 2023

Cancer-specific AI identifies multi-modal biomarkers of therapeutic response for 1,951 drugs including TNG348, a highly selective USP1 inhibitor

Adam Yaari, Lee McDaniel, Antoine Simoneau, Samuel Meier, Oliver Priebe, Eduardo Farias, Alan Huang, Jannik Andersen, Yi Yu, & Maxwell Sherman

June 20, 2022

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

Maxwell Sherman, Adam Yaari, Oliver Priebe, Felix Dietlein, Po-Ru Loh, & Bonnie Berger


Articles